VTLSS: Computational Microscopy of SARS-CoV-2 🦠

I will discuss our lab’s efforts, together with collaborators, to use computational microscopy to understand the SARS-CoV-2 virus in atomic detail, with the goals to better understand molecular recognition of the virus and host cell receptors, antibody binding and design, and the search for novel therapeutics. I will focus on our studies of the spike protein, its glycan shield, its interactions with the human ACE2 receptor, our ACM Gordon Bell Special Prize winning efforts to model the SARS-CoV-2 virion, and escape variants.