Metabolism Deep Dive: Complete Guide to Fatty Acid Synthesis Part 2 🧬

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Ninja Nerds!
In Part 2 of our Fatty Acid Synthesis series, Professor Zach Murphy concludes the pathway by walking through how malonyl-CoA is progressively converted into palmitate, a 16-carbon saturated fatty acid. This lecture focuses on the structure and function of the fatty acid synthase (FAS) complex, highlighting its multi-domain architecture and how it orchestrates the repeated cycles of condensation, reduction, dehydration, and elongation to form the fatty acid chain.

You’ll learn how each domain within FAS—such as the acyl carrier protein (ACP) and ketoacyl synthase—plays a specific role in the stepwise addition of two-carbon units, with NADPH providing the necessary reducing power. The lecture also discusses how newly synthesized palmitate can be further elongated or desaturated depending on cellular needs.

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