Grey's Anatomy S22E5 Trailer: Shocking Twists & Preview
Grey's Anatomy S22E5, 'Sometimes I Feel Like a Motherless Child,' airs Nov 6, 2025. Jo's storyline and more surprises await! 💉

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2.5K views • Oct 31, 2025

About this video
Grey's Anatomy Season 22 Episode 5, titled "Sometimes I Feel Like a Motherless Child," is set to air on November 6, 2025. Here's what we know so far:
Jo will likely face a difficult decision regarding a pregnant mother's case, testing her medical skills and emotional strength. This storyline may also explore Jo's personal struggles and relationships with her colleagues.
Simone's patient will probably reveal a shocking secret, impacting Simone's personal life and relationships with her colleagues. This could create tension and conflict among the hospital staff.
Ellen Pompeo's limited appearances will likely make every episode count, with Meredith's storylines being crucial to the overall plot. Expect significant developments in her character's journey.
The aftermath of the explosion will likely continue to impact Link's storyline, with his fate still uncertain. The show may reveal the extent of his injuries or his status as a potential love interest for Jo.
Teddy's relationship with Owen might still be a point of tension, especially with her growing connection with Cass. Expect emotional moments and potential conflicts between the two.
New relationships might blossom, while existing ones could face challenges. The hospital's renovation and chaotic environment will likely create opportunities for characters to bond or clash.
The episode will likely explore the emotional depth of the characters, with a focus on their personal struggles and relationships.
Expect high-stakes medical crises and intense surgical scenes, showcasing the doctors' skills and teamwork.
The show will likely maintain its suspenseful tone, keeping viewers engaged and invested in the characters' stories.
Jo will likely face a difficult decision regarding a pregnant mother's case, testing her medical skills and emotional strength. This storyline may also explore Jo's personal struggles and relationships with her colleagues.
Simone's patient will probably reveal a shocking secret, impacting Simone's personal life and relationships with her colleagues. This could create tension and conflict among the hospital staff.
Ellen Pompeo's limited appearances will likely make every episode count, with Meredith's storylines being crucial to the overall plot. Expect significant developments in her character's journey.
The aftermath of the explosion will likely continue to impact Link's storyline, with his fate still uncertain. The show may reveal the extent of his injuries or his status as a potential love interest for Jo.
Teddy's relationship with Owen might still be a point of tension, especially with her growing connection with Cass. Expect emotional moments and potential conflicts between the two.
New relationships might blossom, while existing ones could face challenges. The hospital's renovation and chaotic environment will likely create opportunities for characters to bond or clash.
The episode will likely explore the emotional depth of the characters, with a focus on their personal struggles and relationships.
Expect high-stakes medical crises and intense surgical scenes, showcasing the doctors' skills and teamwork.
The show will likely maintain its suspenseful tone, keeping viewers engaged and invested in the characters' stories.
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Views
2.5K
Likes
6
Duration
1:45
Published
Oct 31, 2025
User Reviews
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