Claude AI Co-Founders Share AI's Impact with Oprah ๐ค
Dario and Daniela Amodei discuss how AI influences our lives in a chat with Oprah. Subscribe for more insights!

Oprah
11.2K views โข May 19, 2026

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The siblings and co-founders of Claude AI, the CEO, Dario Amodei, and the President, Daniela Amodei, sit down with Oprah for an in-depth discussion on Artificial Intelligence and its profound impact on all of us. Anthropic is one of the largest tech companies leading AI development including their enormously popular chatbot assistant Claude. Dario and Daniela discuss the ethical responsibility and moral questions that come with creating advanced A.I., their new model Mythos and share their thoughts around government regulation. They talk about the potential risks and benefits of A.I. in everyday lives, the impact on jobs and how it will affect children. The Amodei siblings also explain their headline-making refusal of the Pentagonโs request to remove guardrails from Claude and the behind-the-scenes discussions that helped shape their decision.
00:00:00 - Welcome Daniela and Dario Amodei, founders of Anthropic
00:01:47 - Dario on human extinction
00:04:40 - What is the AI race
00:08:00 - Athropicโs safety concerns
00:09:26 - Why they are a public benefit corporation
00:11:20 - How the siblings formed Anthropic
00:13:00 - Can AI be created responsibly
00:14:12 - Benefits and the harms
00:18:52 - People falling in love with AI
00:20:30 - Claude and underage users
00:22:18 - How Claude does not incentivize users
00:28:33 - Anthropicโs refusal to remove guardrails
00:35:10 - Hard decisions they have had to make
00;38:35 - What regulation should look like
00:40:45 - Should people view AI negatively?
00:43:00 - The AI problem to solve
00:48:20 - Men use AI more than women
00:49:30 - What is Mythos
00:53:20 - Does this keep them up at night?
00:54:15 - What keeps ego in check
00:58:20 - Will they get this right?
00:59:15 - Are there others doing this responsibly?
01:03:25 - What is the meaning of a well-lived life?
Follow Oprah Winfrey on Social:
https://www.instagram.com/oprahpodcast/
https://www.facebook.com/oprahwinfrey/
Listen to the full podcast:
https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI
https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381
The siblings and co-founders of Claude AI, the CEO, Dario Amodei, and the President, Daniela Amodei, sit down with Oprah for an in-depth discussion on Artificial Intelligence and its profound impact on all of us. Anthropic is one of the largest tech companies leading AI development including their enormously popular chatbot assistant Claude. Dario and Daniela discuss the ethical responsibility and moral questions that come with creating advanced A.I., their new model Mythos and share their thoughts around government regulation. They talk about the potential risks and benefits of A.I. in everyday lives, the impact on jobs and how it will affect children. The Amodei siblings also explain their headline-making refusal of the Pentagonโs request to remove guardrails from Claude and the behind-the-scenes discussions that helped shape their decision.
00:00:00 - Welcome Daniela and Dario Amodei, founders of Anthropic
00:01:47 - Dario on human extinction
00:04:40 - What is the AI race
00:08:00 - Athropicโs safety concerns
00:09:26 - Why they are a public benefit corporation
00:11:20 - How the siblings formed Anthropic
00:13:00 - Can AI be created responsibly
00:14:12 - Benefits and the harms
00:18:52 - People falling in love with AI
00:20:30 - Claude and underage users
00:22:18 - How Claude does not incentivize users
00:28:33 - Anthropicโs refusal to remove guardrails
00:35:10 - Hard decisions they have had to make
00;38:35 - What regulation should look like
00:40:45 - Should people view AI negatively?
00:43:00 - The AI problem to solve
00:48:20 - Men use AI more than women
00:49:30 - What is Mythos
00:53:20 - Does this keep them up at night?
00:54:15 - What keeps ego in check
00:58:20 - Will they get this right?
00:59:15 - Are there others doing this responsibly?
01:03:25 - What is the meaning of a well-lived life?
Follow Oprah Winfrey on Social:
https://www.instagram.com/oprahpodcast/
https://www.facebook.com/oprahwinfrey/
Listen to the full podcast:
https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI
https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381
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Video Information
Views
11.2K
Likes
458
Duration
01:06:15
Published
May 19, 2026
User Reviews
4.6
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