004 From Gene to Organism: Understanding Developmental Control Programs

Visit www.scienceexpressinap.org.in for more information. <br /> <br />Which programs control the development of life? <br />Like many organisms, a human being develops from a single cell. Today, the human genome has been completely decoded. Surprising discovery: our blueprint contains many molecular similarities to other living beings. But how does a organism develop from such a plan? How can completely different cells develop from one set of genetic information? Cells react with their surroundings, making use of different nutritional sources, repairing defects, and coordinating their activities in the growth and development cycle. How does the cell use the information encoded in the genome to fulfil its function? We know that an organism is not defined only by its genes. In addition to protein-encoded areas, DNA also contains regions that control the gene expression. <br />This explains why the number of genes does not continue to rise as the organism becomes more complex, or consequently why the same number of genes can produce a mouse or a per-son. But how do genes interact in networks, and what influence do external factors exert? Many afflictions, such as cancer, cardiovascular diseases and diabetes, result from the interactions of numerous genes and environmental factors. What is the difference between a sick and a healthy organism? <br />How can the natural control system be used for new therapy forms? Can we reprogram body cells? Today, researchers have the chance to study and understand life as a complex “system”. Together with new technologies, this could lead to new medicines that treat illnesses according to the individual genetic disposition.